The indexes have already been bolstered in recent weeks by trade optimism and dovish signals from the Fed, with the S&P 500's session high just 4.7 percent away from its record closing high in September.
The Dow Jones Industrial Average fell 33.97 points, or 0.13 percent, to 26,057.98, the S&P 500 lost 2.21 points, or 0.08 percent, to 2,793.9 and the Nasdaq Composite dropped 5.16 points, or 0.07 percent, to 7,549.30.
The S&P's biggest losing stock was JPMorgan Chase & Co, which closed down 0.8 percent after it warned of rising costs for deposits, a key part of its business, and slowing global economic growth.
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