The S&P 500 energy index added 0.57 percent as Brent oil hit a four-year high, boosted by imminent US sanctions on Iranian exports, and OPEC and Russia's reluctance to raise output.
The Dow Jones Industrial Average fell 0.26 percent to end at 26,492.21 points, and the S&P 500 lost 0.13 percent to 2,915.56.
The Nasdaq Composite rose 0.18 percent to 8,007.47. Amazon.com Inc provided the greatest lift to the technology-heavy index, jumping 2.08 percent.
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