MSCI broadest index of Asia-Pacific shares outside Japan fell 0.2 percent, while the Australian benchmark also dropped 0.2 percent.
Japan's Nikkei average was flat, and appeared to struggle for headway. Data out earlier in the day showed exports from the world's third-biggest economy dropped for the first time since late 2016, hit by declines in shipments to the United States and China.
The US dollar index and Treasury yields rose to its highest levels in a week on Wednesday.
The dollar index, which measures its value against six major peers, last traded at 95.654, little changed on the day, while 10 year Treasury yield last stood at 3.211 percent, 3.2 basis points higher than the US close.
The minutes from the Fed’s Septa 25-26 meeting showed every Fed policymaker backed raising interest rates last month and also generally agreed borrowing costs were set to rise further, despite US President Donald Trump’s view that the tightenings have already gone too far.
Major currencies have shown limited reaction after the US government late on Wednesday refrained from naming China or any other trading partner as a currency manipulator, as it leans on import tariffs to try to cut a trade deficit with China, soothing investor sentiment in Asia.
In its semi-annual currency report, the US Treasury Department said a recent depreciation of China’s yuan currency will likely exacerbate the US trade deficit, but US officials found Beijing appeared to be doing little to directly intervene in the currency’s value.
The yuan was steady at 6.9315 per dollar in the offshore trade, not far off 1-1/2-year low of 6.9587 touched in August.
But some investors remain wary of a slide towards the psychologically important level of 7 to the dollar.
“With US Treasury yields beginning to creep higher again, President Trump hinting at further tariffs on Chinese goods and the CSI 300 trading at close to its lowest level since the summer of 2016, the continued risk of a fresh bout of weakness (in the yuan) cannot be ignored,” said Simon Derrick, chief currency strategist at BNY Mellon.
In Europe, the European Council meeting kicked off on Wednesday with a roundtable dinner, with British Prime Minister Theresa May’s address ahead of it, though expectations that anything substantial will come out of it have already been fading.
“Hopes for Brexit deal has supported the pound for the past two months. So if there’s no meaningful development, other than longer transition period, the pound could come under short-term selling pressure,” said Tohru Sasaki, head of markets research at JPMorgan Chase Bank in Tokyo.