The Ministry of AYUSH has approved a proposal for carrying out a clinical study to assessthe role ofVasa and Guduchi in therapeutic management of symptoms in COVID-19 positive patients. This will be a randomized, open label three armed study, and will be conducted at the All India Institute of Ayurveda (AIIA), New Delhi, in collaboration with the IGIB unit of CSIR, the ministry said.In view of the need for accelerated solutions for COVID-19, the Ministry of AYUSH has taken up systematic studies on different possible solutions through multiple channels. "As part of this effort,a proposal for a clinical studyto assessthe role ofVasa Ghana, Guduchi GhanaandVasa-Guduchi Ghanain therapeutic management of symptoms in COVID-19 positive cases has recently been approved," the ministry said in a statement.The detailed proposal with methodology including outcome measures, clinical andlaboratory parameters, the logistics of the research has been prepared. The study will use a unique case report forum (CRF), suitable for Ayush mode research. The CRF and study protocol has also beenpeer reviewed by experts from different domains including modern medicine and their suggestions have been incorporated.The study will be undertaken subject to the required approvals like that of the Institutional Ethics Committee (IEC).The project would look into theefficacy/action of mono-herbal formulations of whole extracts ofVasaand Guduchirespectively, and polyherbal formulation ofVasa-Guduchiwhole extract on therapeutic management of SARS-CoV2 positive asymptomatic and/ or mild COVID-19 symptomatic cases. Theproject would also assess the impact of the formulations on the speed of viral replication and "Whether the said mono-herbal and polyherbal formulations can alter the expression profiles of keybio markers associated with COVID-19 disease," the statement said.VasaandGuduchiare time tested herbs in Indian healthcare traditions, used in a variety of disease conditions. The outcome of this study would therefore be of considerable interest to the entire Ayush sector, the ministry said.